Pregnancy Tests: Diagnostic pregnancy assessments depending on immunological reactions in between HCG and anti-HCG might lead to false-damaging or Untrue-positive interpretations.
For nausea and vomiting in young children, the same old dose is 0.five mg for every pound of overall body excess weight, and the dose must be altered towards the age and body weight of the affected person along with the severity of your situation currently being dealt with.
Sedation in both equally children and Older people, and also relief of apprehension and creation of mild slumber from which the individual is often quickly aroused.
Promethazine hydrochloride happens being a white to faint yellow, pretty much odorless, crystalline powder which slowly but surely oxidizes and turns blue on prolonged publicity to air.
Codeine resembles morphine both equally structurally and pharmacologically, but its actions within the doses of codeine used therapeutically are milder, with a lot less sedation, respiratory depression and gastrointestinal, urinary, and pupillary outcomes. Codeine makes an increase in biliary tract tension, but a lot less than morphine or meperidine. Codeine is a lot less constipating than morphine.
Codeine may perhaps enrich the neuromuscular blocking action of skeletal muscle mass relaxants and generate an elevated degree of respiratory despair.
Anticholinergics - Concomitant use of other brokers with anticholinergic Houses must be undertaken with warning.
Advise people to generally use an correct milliliter measuring gadget when measuring and administering Promethazine HCl and Codeine Phosphate Oral Solution. Notify individuals that a house teaspoon isn't an accurate measuring unit and such use could lead to overdosage and serious adverse reactions [see Overdosage (10)].
sedation, reduction of panic, and creation of light-weight slumber from which the patient can be simply aroused
Avoidance and control of nausea and vomiting linked to sure varieties of anesthesia and operation.
Postmarketing conditions of respiratory depression, together with fatalities, are already reported with utilization of promethazine hydrochloride in pediatric people below two a long time of age. A variety of bodyweight-dependent doses of promethazine hydrochloride have resulted in respiratory depression in these individuals.
Cure: The procedure of overdosage with promethazine and codeine is actually symptomatic and supportive. Only in situations of utmost overdosage or read more individual sensitivity do important indications like respiration, pulse, hypertension, temperature, and EKG should be monitored. Activated charcoal orally or by lavage may be given, or sodium or magnesium sulfate orally as being a cathartic. Focus needs to be presented to your reestablishment of suitable respiratory Trade by provision of the patent airway and institution of assisted or controlled air flow.
Human Information Printed info from situation-Management and observational scientific tests on codeine use all through pregnancy are inconsistent of their conclusions. Some scientific tests of codeine publicity showed an increased threat of General congenital malformations while others didn't.
Caution must be exercised when administering Promethazine HCl Oral Alternative to pediatric patients two years of age and more mature due to potential for fatal respiratory despair. Respiratory despair and apnea, sometimes related to death, are strongly related to promethazine items and therefore are not directly associated with individualized excess weight-primarily based dosing, which could if not allow Risk-free administration.